Angiopoietin-2 in sepsis: lost in translation?
نویسندگان
چکیده
Iyoda et al. have provided strong experimental evidence forbeneficial effects of PDGF signalling inhibition in two see-mingly unrelated glomerular diseases: rapidly progressive glo-merulonephritis (RPGN) in the present study and focal andsegmental glomerulosclerosis (FSGS) in a previous study.Novel insights into the pathogenesis of these two diseaseshave unravelled a common cellular mechanism: activation ofparietal epithelial cells (PECs). In addition, recent studieshave shown that PDGF signalling is sufficient to mediate thePEC activation and formation of cellular crescents, the hall-mark of RPGN. In this comment, we make an attempt to as-semble the pieces of the puzzle arguing that the activatedPECs might play a significant role and could represent atarget for novel treatment strategies for RPGN and FSGS.Rapidly progressive glomerulonephritis (RPGN) is charac-terized by proliferating cells within Bowman’s space, whichtypically form crescentic accumulations. RPGN is associatedINFOCUS © The Author 2012. Published by Oxford University Press onbehalf of ERA-EDTA. All rights reserved.489
منابع مشابه
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عنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 28 3 شماره
صفحات -
تاریخ انتشار 2013